Discovery and Mental Models

Drug discovery and mental illness

Mental disorders are among the most disabling of all diseases. Effective well-documented medications have been available for many decades. Yet, limited understanding of the pathophysiology of mental disorders has impeded the development of novel treatments. Drug discovery must move toward a net* mechanism-based paradigm using the tools of contemporary genetic and molecular medicine. At the same...

Mental Models 1 Running head: MENTAL MODELS Mental Models of Complex Systems: Structure and Function

Interacting with complex systems such as organizations and mechanical devices is an integral part of our lives. Learning them can be a challenge, although they can be described in language and depicted in diagrams. Medium, verbal or graphic, and ability/expertise have had conflicting effects on acquisition. Those effects are clarified by recognizing that complex systems have structural organiza...

Mental Models and Causation

The theory of mental models accounts for the meanings of causal relations in daily life. They refer to seven temporallyordered deterministic relations between possibilities, which include causes, prevents, and enables. Various factors— forces, mechanisms, interventions— can enter into the interpretation of causal assertions, but they are not part of their core meanings. Mental models represent ...

Mental models and consistency

Discovery Sampling and Selection Models

Various aspects of Bayesian inference in selection and size biased sampling problems are presented beginning with discussion of general problems of inference in in nite and nite populations subject to selection sampling Estimation of the size of nite populations and inference about superpopulation distributions when sampling is apparently informative is then developed in two speci c problems Th...